Tribute to Janis Joplin (2005)
With Joss Stone and Melissa Etheridge
Intended to mark the 35th anniversary of Janis Joplin's tragic overdose, the fiery duet is better remembered as Melissa Etheridge's comeback following her excruciating treatment for breast cancer. Joss Stone primed the crowd with an impassioned "Cry Baby" before Etheridge — bald from chemotherapy — took the stage. Her entrance brought the usually staid Grammy audience to rapturous applause. Having recently endured a lumpectomy, she turned "Piece of My Heart" into an anthem for breast-cancer survivors around the world.
"It was an opportunity for me to prove to myself that I could get back on the stage," Etheridge later said of the performance. "This symptom of cancer that I had was not going to stop me, kill me, change me. I was actually going to be better after this and that the chemotherapy that was just sucking the life force out of me wasn't going to keep me down."