28. Eminem, "Lose Yourself"
Eminem's biggest hit ever plays like Rocky condensed into a five-minute song. It helped that in telling the story of Rabbit – the trailer-dwelling aspiring rapper he played in 8 Mile – Eminem was writing autobiographically, sidestepping demented hijinks and pure rage in favor of tough realist rhymes about overcoming very long odds. Em cut the song during a brief break from filming. "He came in and laid down all three verses in one take," said engineer Steven King. "Jaws dropped – we were like, 'Oh, my God! This story has been building in him.'"