10. "Meet the Parents"
The premise of Meet the Parents is rather simple: A neurotic, recently-engaged male nurse with the unfortunate name of Gaylord Focker heads to the suburbs of Long Island with his fiancée to meet her parents. With a cast that includes Ben Stiller, Robert De Niro, Blythe Danner and Owen Wilson, it resulted in a surprise comic masterpiece. De Niro has never been funnier than as the overbearing, former CIA future father-in-law, while Stiller's slow breakdown in the face of constant, humiliating setbacks is brilliantly played. The 2000 movie grossed $300 million and launched two sequels, though none live up to the original.