It Takes Two: Top 25 Best Buddy Comedies

From mismatched cops on a job to teenage best friends going out in a blaze of glory, we count down the

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'Midnight Run' (1988)
Universal/Courtesy Everett Collection2/25

2. 'Midnight Run' (1988)

Odd couples don't come much odder than Robert De Niro's tempestuous bounty hunter and Charles Grodin's fugitive accountant, thrown together as they travel cross-country and try to avoid mobsters and the Feds. Apart from a handful of movies early on in his career and a cameo in Brazil, De Niro hadn't much of a chance at that point to show audiences how funny he could be. But after spending much of Midnight Run trying not to blow his top over Grodin's obsessive-compulsive futzing around, there was no question he could do slow-burn comedy as well as intense, you-talkin'-to-me dramas. Martin Brest's direction hits the requisite Eighties action-movie marks, but it's De Niro and Grodin, sparring and eventually softening like Bogart and Bacall in The African Queen, that give the movie a surprising sweetness.—SAM ADAMS

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