'The Simpsons': 'Lisa's Substitute' (1991)
The name in the credits is listed "Sam Etic" – but you'd know that voice anywhere. Hoffman lent his celebrity pipes to this classic, popular Simpsons episode in which Lisa develops a crush on her substitute teacher Mr. Bergstrom – the kind of left-of-center educator that dresses up as a cowboy to get kids' attention, reads Charlotte's Web aloud and suggests his own derisive nicknames. (When it's mentioned that there were no Jews riding the range in the 1830s, he issues a correction: "There were a few Jewish cowboys ... big guys, who were great shots, and spent money freely.") As with most good things, her dream professor's tenure eventually comes to an end, but not before Bergstrom gives her a self-affirmation note that simply reads, "I am Lisa Simpson." There's so much humanity and humor that Hoffman puts into this animated Mr. Chips that you can see why the smartest Simpson would swoon over him; the part also proves that Dustin can do a crack, albeit highly footnoted rendition of "Home on the Range."