1. Julianne Moore, 'Still Alice'
In 1995, Julianne Moore, still relatively unknown at the time, essayed one of the great modern film roles in Safe, playing a suburban housewife who's allergic to the world, a condition that results in her practically disappearing in front of our eyes. Almost 20 years later, now firmly established as one of our best actresses, Moore delivered another astounding performance about a different woman losing herself. Still Alice tells the story of a linguistics professor diagnosed with early-onset Alzheimer's, and the actress plays her as a bright, poised 50-year-old who quickly learns that her intelligence can't save her from a disease that will ravage her memory. It's a performance that's powerfully internal yet expressed with incredible physicality: The woman's fear, resignation and anger come through in Moore's panicked, anguished eyes, but what's especially remarkable is how she articulates the emptying out of a once-vibrant person. Alice is still there, and yet she's not, and the star honors the mysteries of a body that's lost its inner light and yet retained its ineffable soul.