Kumail Nanjiani, 'The Big Sick'
You know those screenings where the audience is laughing so hard at jokes that you end up missing the four or five lines that follow them? That happened dozens of times during the premiere of this semi-autobiographical comedy-drama about a Pakistani stand-up dealing with his new girlfriend's near-fatal medical condition – and it's all thanks to Kumail Nanjiani. The Silicon Valley star's deadpan comic timing is the not-so-secret weapon here, whether he's trading barbs with fellow club comedians, bantering Ray Romano and Holly Hunter's out-of-towners or defusing his own family's culture clashes. The fact that he and Zoe Kazan also have incredible onscreen chemistry as well only sweetens the deal. Meet your new rom-com leading man.