49. Fred Armisen and Carrie Brownstein, 'Portlandia'
He's a graduate of Saturday Night Live. She's an alum of … Sleater-Kinney? It looks odd on paper, but this chameleonic combination of a musician/sketch comedian and a punk-rock icon is somehow the perfect weapon when it comes to skewering the pretensions of Pacific Northwest hipsterdom. Their portrayal of Toni and Candace — the quarreling couple who maintain the probelmatically unproblematic feminist bookstore in the show's most famous recurring sketch — is enough to assure them immortality on its own.