3. Tina Fey and Amy Poehler, 'Saturday Night Live'
Today "Weekend Update," tomorrow the world. These women paired with future late-night titans Jimmy Fallon and Seth Meyers on either side of their fake-newscaster reign together — and with all due respect to Jane Curtain and Dan Aykroyd, Colin Jost and Michael Che, etc., no duo has occupied that desk better. (Their recent joint return as dual SNL hosts has been the highlight of this season; see that "Meet Your Second Wife" sketch.) Fey and Poehler parlayed their time on Saturday Night Live into careers as comedy moguls, movie stars and Golden Globe co-hosts, but they're the most powerful power couple in TV history, full stop.