27. Spongebob Squarepants and Patrick, 'Spongebob Squarepants'
He's lived in a pineapple under the sea for 17 years and counting, during which time he became Nickelodeon's highest-rated, most licensed (and lucrative) longest-running franchise. But the success of the squeaky-voiced, eternally optimistic sea sponge known as Spongebob Squarepants would be unimaginable without the support of his good-hearted, dim-witted starfish neighbor and best friend Patrick. Voiced by comedian Tom Kenny —a key player in cartoons from Powerpuff Girls to Adventure Time — and Coach's Bill Fagerbakke respectively, their (mostly) kid-friendly comedic chemistry proves you don't necessarily need brains to be brilliant.