26. Bob Odenkirk and David Cross, 'Mr. Show With Bob and David'
When it comes to American sketch comedy, there's everything before Mr. Show and everything after. Bespectacled standup David Cross and future Better Call Saul star Bob Odenkirk's HBO vehicle paired their sardonic sensibilities to essentially create alternative comedy as we know it. And while their two-man tag-team dominated the show, they were more than willing to share the spotlight with a who's who of future stars, including Sarah Silverman, Paul F. Tompkins, and fellow Greatest Duo luminaries Tom Kenny (Spongebob Squarepants) and Mary Lynn Rajskub (24).