16. Frasier and Niles Crane, 'Frasier'
Move over, Noel and Liam Gallagher: The Crane boys were the Nineties greatest brother act. It took a stroke of mad brilliance to take the fuddy-duddy punchline of a thousand Cheers jokes and pair him with an even fussier, prissier culturati for his spinoff series. But that's the dynamic between the iconic Kelsey Grammer character and his baby bro, played by David Hyde Pierce. Whether trading barbs that required an Ivy League education to decipher or engaging in slapstick farce that put the Three Stooges to shame, Frasier and Niles were one of of Must-See TV's best double acts.