11. Larry Sanders and Hank Kingsley, 'The Larry Sanders Show'
Johnny Carson and Ed McMahon. David Letterman and Paul Shaffer. Conan O'Brien and Andy Richter. These were the duos that defined late-night televison — but the late, great Garry Shandling's groundbreaking sitcom took them one step further. Played by Shandling and Jeffrey Tambor, the obnoxious talk-show host Larry Sanders and obsequious henchman Hank Kingsley at the heart of HBO's seminal showbiz parody sent up Hollywood narcissism, back-scratching, and ass-kissing better than any real-world equivalent could. At the same time, the duo served up a demented celebration of the showman-and-sidekick relationship around which the entire after-hours TV landscape is patterned. No flipping.