1. Mulder and Scully, 'The X-Files'
Can professional ethics, intellectual antagonism, unyielding loyalty, platonic friendship, and raw sexual tension all get along? I want to believe. Put simply, Dana Scully and Fox "Spooky" Mulder were, and are, the most complex and compelling male-female partnership ever to be put on the small screen. Mulder's fanaticism and Scully's skepticism, her cool and his heat, David Duchovny's irresistible sex appeal and, uh, Gillian Anderson's irresistible sex appeal — X-Files creator Chris Carter could not have created a better pair of FBI agents to embody his series' pre-millennium paranoia, nor cast two better actors to play them. Friends, rivals, partners, lovers — they're every great TV duo all at once, which makes them the greatest of all.