5. Cersei Lannister
As a woman, the matriarch of the Lannister clan battles for a place at the table in a world made for men, by men. As a mother, she'd do anything to protect her inbred brood, though her schemes have led directly to their deaths. As a player of the game, she coined the show's catchphrase: "You win or you die." And she'd rather die than give you control. Now she sits the Iron Throne herself, her enemies dead and her most loyal followers – Jaime and her fearsome undead bodyguard the Mountain – are by her side. Reign in blood, Your Grace.