5. William Shatner
Captain James T. Kirk casts a long shadow here, but Shatner has enough strange hobbies — e.g. spoken word, being a weirdo in commercials — to keep things interesting. George Takei and Nichelle Nichols hold it down for the crew of the Enterprise; the rest of the dais of comics and nerd-comics — give it up for Patton Oswalt — toy with Shatner's ego while avoiding Andy Dick, who manages to lick the faces of nearly everyone onstage. This night may have also been the first time people got excited about perky Betty White talking dirty: "We all know Shatner's nuts, but George has actually tasted them!" No one boldly goes where no man has gone before in terms of ribbing Bill for his lack of acting chops, but with this much comic force kicking into warp speed, they don't need to.