David Letterman's Top 10 Musical Moments
David Letterman onstage with the Foo Fighters and Zac Brown on 'Late Show with David Letterman,' Monday Oct. 13th, 2014. Jeffrey R. Staab/CBS

When David Letterman permanently signs off the airwaves later this month, it won't just be the end of one of the greatest comedy institutions in TV history — it'll also close out an amazing showcase for musical talent. Nearly every episode of NBC's Late Night With David Letterman and CBS's Late Show With David Letterman had a musical guest, and it was the place where many Americans first saw everyone from R.E.M. and Weezer to Future Islands. We've put together 10 of the greatest musical moments from the shows' history, and though the list is by no means complete — we could easily have gone to 100 — these are the performances we keep returning to over and over again.