26. Agent Denise Bryson
I want to believe! DEA Agent Denise Bryson provides a bridge to the Nineties other great network-TV supernatural mega-mystery, The X-Files, by virtue of the fact that she's played by none other than David Duchovny. She's also a respectfully treated transgender character in an era where that was extremely rare. Though her fellow feds knew her when she presented as male, their reaction to her arrival in Twin Peaks (to investigate bogus drug charges against Coop) is basically just, "Well, okay, cool. Hi Denise, glad to have you aboard."