46. 'The Mary Tyler Moore Show'
Hail Mary: the ultimate template for how to make comedy gold out of being a grown-up neurotic making it on your own in the big city. She worked in a Minneapolis TV newsroom full of cranks like Ted Knight's windbag anchorman and Ed Asner's hard-drinking boss, Lou Grant. ("I haven't been this mad at anybody since 1944." "Did anything much happen?" "I captured a town in Germany.") Revolutionary at the time, blasé about sex and birth control, it also pioneered the all-too-rare concept of going out on top – it signed off in 1977, a massive hit to the end. Every sitcom still steals from MTM, but Moore's heart and soul remain one of a kind.