"Voodoo Chile" took the funky blues of greats like Muddy Waters and John Lee Hooker into the psychedelic age, the 15-minute track putting Jimi Hendrix's guitar improvisations into a loose jam-like setting. Backing him were Jimi Hendrix Experience drummer Mitch Mitchell, Jefferson Airplane bassist Jack Casady (subbing for usual Experience bassist Noel Redding) and Traffic's Stevie Winwood on organ, with guitarist Larry Coryell declining an invitation to join them. "Jimi asked me to play," Coryell recalled, "but for the first time in my life, I said, 'No. There is nothing I can add to this.'"
This song wasn't part of the planned track listing for 2007's Echoes, Silence, Patience & Grace, and was put together in a day. "It happened after we recorded a lot of stuff," said Dave Grohl. Yet it ended up as the album opener and the lead single. Grohl called it "a stomping Foo Fighters uptempo song with a little bit of Chuck Berry in it." The singer hinted at the lyrics' political overtones: "Everyone's been f---ed over before and I think a lot of people feel f---ed over right now and they're not getting what they were promised."