Hip-hop band De La Soul included "Me Myself and I" on their debut album, but the song almost didn’t make it on the project. "That was the second to last song recorded for that album," band member Posdnus told Rolling Stone. "[Our label] Tommy Boy was loving how the album was going, but they felt like we needed an introduction song. That was the first time on this album where it was brought to our attention that we may need to make sure we have something that isn't so over someone's head." The song was also used for an episode of the HBO series, "Entourage."