4. 'Tears in Heaven'
There are about three people on the planet who remember the 1991 Jennifer Jason Leigh movie Rush. It's about two undercover cops who become drug addicts. The handful of people who saw it in the theaters were the first to hear "Tears in Heaven." Eric Clapton composed the soundtrack, and he included a new song he wrote about the tragic death of his four-year-old son, Conor. The video played in a constant loop on VH1 for months on end and shortly afterward, Clapton rerecorded the song for Unplugged, giving it another boost on the charts. It became one of the biggest hits of Clapton's career, but by 2004, he could no longer face singing the song and he dropped it from his setlist.