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20. "Drowned World/ Substitute for Love" (from 'Ray of Light,' 1998)

Between 1994's Bedtime Stories and 1998's Ray of Light, Madonna became a mother, giving birth to her daughter Lourdes. She addressed that life-changing moment on Ray of Light's opening track, a ballad exploring epiphanies about fame and family. "I got pregnant, and the whole idea of giving birth and being responsible for another life put me in a different place," she said in 1998. "People have been obsessed with the idea that I am always reinventing myself, [but] I'd rather think that I'm slowly revealing myself."