Eminem swept four categories, including favorite hip hop artist, favorite male musician, favorite music video and favorite song for "Love the Way You Lie," his hit with Rihanna.
Katy Perry took home trophies for being voted favorite female artist and favorite web celebrity. When accepting an award, the singer exclaimed "I've had an incredible year!" No kidding.
Other winners, determined by a record-setting 175 million votes cast online, included Usher for favorite R&B artist and Taylor Swift for favorite country artist.
"Twilight" and Katy Perry among People's Choice winners [Reuters]
"Twilight," "House" Top People's Choice Awards [Hollywood Reporter]