On Monday, the 35-year-old Chelsea Lately host tweeted a photo of herself planting a kiss on the rapper's cheek as the two cuddled in bed.
"I don't know why anyone thinks I would ever date a rapper," Handler teased in the caption.
The duo were first spotted together in October when they shared a romantic evening at a New Orleans bar. "It's been going on for a while," a source told UsMagazine.com at the time. "It's more of a hookup thing — whenever they are in the same town."
Perhaps things are getting more serious between the twosome: 50 Cent (real name: Curtis Jackson) visited the comedienne in Newark, NJ just last week — the same weekend she called Angelina Jolie "a homewrecker" and a "f***ing c***" during her stand-up act.