Tolian Soran, as played by the excellently malicious Malcolm McDowell in 1994's Star Trek Generations, was pretty much your standard mad scientist: Crazy glint in his eye, wants to take over the universe – that kind of thing. So how did he make it to the Top Three? By killing Captain Kirk. This bastard did what countless aliens and lunatics tried and failed to do over the course of three seasons and seven films – he actually knocked off our hero, and all because of some stupid interdimensional ego trip. We're getting mad just thinking about it.