1. Kanye West feat. Pusha T, "Runaway"
It takes a special kind of dark, twisted genius to raise the white flag of surrender while raising a middle finger. Kanye West is that genius. "Runaway" is Kanye's musical response to the Taylor Swift affair, but it's much more than that: a nine-minute meditation on romantic failure and public infamy. Kanye creates a huge, eerie beat out of thunderous drums and plinking piano, and he turns the phrase "Let's have a toast for the douchebags" into a refrain nearly as catchy as "She loves you — yeah, yeah, yeah." In 2010, no other song was so crazily epic or jaw-droppingly gorgeous — not on the radio, not anywhere. Now, everyone raise your glasses.