Guitarist Buddy Guy — one of the last working giants from the electric blues' greatest generation — traces his life in mission and missing, from the crackling title cut to the B.B. King memorial "Flesh and Blood," sung with Van Morrison, and "Come Back Muddy," a message to Guy's late boss, Muddy Waters. Guy co-wrote just four songs here, but he sings and solos with reliable ferocity; two tracks with harpist Kim Wilson evoke his classic partnership with Junior Wells. "I was born to play the guitar/People, I got blues running through my veins," Guy sings — lines he didn't write but lived. In the blues, that's what matters.