22. 'Dr. Strangelove'
Stanley Kubrick was coming off the scandal of his big-screen adaptation of Lolita when he decided to film this hysterical cold war spoof. The film features Peter Sellers in multiple roles and deals with some very serious issues — most notably the possible end of the human race through a nuclear holocaust — but it never relents on the comedy for even a second. If anything, the film has only gotten funnier (and more relevant) with age.