The Canadian actress was originally out for the role of Cady, while Lohan relished the chance to play HBIC Regina George, but director Mark Waters swapped the two. McAdams went on to have one of the most famous cinematic embraces of all time with former beau Ryan Gosling in 2004's The Notebook, recreated to steamy effect at the following year’s MTV Movie Awards. (Why couldn't these two make it work?) She's worked steadily ever since, showing up in everything from blockbuster franchise fodder (Sherlock Holmes) and raunchy bro-comedies (Wedding Crashers) to Woody Allen movies (Midnight in Paris). Too often, however, McAdams has found herself stuck in treacly romantic dramas (The Time Traveler's Wife) and even more treacly rom-coms (The Vow, About Time); though she did make 2010's Morning Glory bearable, the attempt to sell her as a next-gen Meg Ryan hasn't quite worked. Next up, she plays a human-rights attorney in one of Philip Seymour Hoffman’s final films, A Most Wanted Man.