Rodriguez confirmed the casting on Twitter, writing, "I just finished working with @LadyGaga on @MacheteKills, she kicked SO MUCH ASS! Holy Smokes. Blown away!" Gaga followed up on her own Twitter account, posting, "Yes its true, I will be making my debut as an actress in the amazing MACHETE KILLS BY @RODRIGUEZ IM SO EXCITED!!! AH! Filming was insane."
Machete Kills is a sequel to Rodriguez's 2010 film Machete and also stars Mel Gibson, Danny Trejo, Amber Heard, Jessica Alba, Sofia Vergara, Zoe Saldana, Charlie Sheen and more. It is scheduled for a 2013 release.