Gran's Death (Season 1, Episode 5)
Sookie's indisputable rock was her "Gran," Adele Stackhouse, who had raised Sookie and her brother, Jason, since their parents' death when the two were kids. Gran had a strong will and an undeniable Southern charm, and was fiercely protective of her granddaughter. So it was all the more heartbreaking when she was murdered in her kitchen midway through Season One. Though Gran's memory served as a kind of inner moral compass for Sookie in the episodes that would follow, one has to wonder how much Sookie's life would have changed if her grandmother had remained alive. Gran did reappear at the end of Season Four to offer guidance, when her spirit called for the witch Marnie to return to the grave. Despite Sookie's pleas for her to stay, Adele remained steadfast and told Sookie that she knew in her heart what to do – a vote of confidence that helped Sookie resolve her Eric and Bill drama (for the time being, at least).