20. John Marston
In Rockstar games missions tend to be handed out by jerks and lunatics. You wonder why the main character bothers with them. Although John Marston from Red Dead Redemption still had to put up with several of those jerks and lunatics, he was refreshingly blunt about it. Like the player, he wasn't interested in their nonsense, responding to the village idiot asking if he can find his lost sweetheart with, "I doubt it. But if I head up that way, I'll see what I can do." (His sweetheart turned out to be a horse.) Marston needed redemption, but he didn't need to be nice about it.
Iconic moment: A familiar cry rings out, "Partner! I need your help!" Marston keeps his head down. "You and every other fool around here," he says.