45. Agent 47
Fans of wrestling know their "Hitman" as “the best there is, the best there was, and the best there ever will be”. Bret Hart’s murderous namesake can claim the same slogan pertaining to the assassination business. Forever emulated yet never bettered, IO’s shaven-headed killer's catalog of death methods dwarfs any traditional cookbook, with resumé highlights that include nudging a garbage man into his own truck, and shooting the glass on the underside of a clifftop hot tub. Agent 47 first found infamy in 2000, and – unlike his many victims – has survived four generations by constantly reinventing himself in all ways other than that bald dome.
Iconic Moment: Hitman: Blood Money was the game where it felt like the creators were really having some fun with the whole "my day job is planning murders" thing. The best example is the Vinnie Sinisitra kill at a kid's birthday party, with the option to get deadly as a FBI operative, a pool boy or even a clown.