First she was a chick-flick queen, starring in films like Sleepless in Seattle and A League of Their Own. Then, a couple of years after bringing the iconic cartoon character Betty Rubble to life in The Flintstones, she became the "Queen of Nice," as the Koosh-flinging, Tom Cruise-adoring host of The Rosie O'Donnell Show, which ran from 1996 to 2002. She was also briefly the queen of the on-air feud, regularly clashing with her conservative View co-host, Elisabeth Hasselbeck over the Bush administration's handling of the Iraq War. But now, Rosie O'Donnell is stepping into the domain previously held by the queen of all media, Oprah Winfrey. This fall, she'll launch a brand-new talk show on Winfrey's OWN channel – which will reside in the soon-to-be vacated studio space in Chicago, where The Oprah Winfrey Show has taped for 25 seasons.