The king of all things uncomfortable, embarrassing, troubling and inappropriate, Galifianakis has become the least likely mega-star of his generation. The Hangover 3 will be out later this year, and last year's The Campaign, with Will Ferrell, was a surprisingly trenchant comment on political corruption. But the Galifianakis magic is often best experienced in situations where his languidly absurdist genius is undiluted – like his appearance as a standup comedian from 1778 ("Is this thing on? What is this thing?") or the web series Between Two Ferns, his now-legendary masterclass in celebrity discomfort. His ability be at once totally unacceptable and utterly lovable is a comedic wonder: "I want to combine the NAACP with Mothers Against Drunk Driving," he once joked. "It's called Mothers Against the Advancement of Colored People."