5. Trey Parker and Matt Stone
Fifteen years ago, South Park was seen as a Beavis and Butt-Head clone – minus the social satire, and with worse animation. Gradually, Trey Parker and Matt Stone's humble creation became the smartest (and most subversive) show on television, finding humor in everything from Scientology to the Special Olympics. Parker and Stone's initial non-South Park projects (Orgazmo, Team America) were mixed bags, but in 2011 their Broadway debut The Book of Mormon became the best reviewed musical in recent memory. The pair just formed a new production company, but Parker and Stone aren't slacking on their day job, either: The most recent season of South Park was as hilarious and batshit-crazy as ever.