21. Tig Notaro
"Thank you. I have cancer. Thank you." And so began Tig Notaro's now-legendary set last August at the Largo in L.A. For 30 minutes, the stand-up riffed bittersweet on her recent breast-cancer diagnosis, the sudden death of her mother, a debilitating intestinal infection and a bad break-up. It was the kind of set her sardonic deadpan for built for. (As were previous gems like "I went on a hardcore drinking and smoking binge, and it lasted right about nine months. And then, as soon as I was born, I was like, 'Whew! Do not go in there.'") Louis C.K. hyped her set on his website, proclaiming, "[I]n 27 years doing this, I've seen a handful of truly great, masterful stand-up sets. One was Tig Notaro last night at Largo." In addition to appearances in upcoming films Walk of Shame and Shreveport, a now cancer-free Notaro is currently planning to work on Amy Schumer's new New York-based show and write a book. She'll always be The Sarah Silverman Program's Officer Tig to us.