50. Michael Che
Born and raised on the Lower East Side, 29-year old Michael Che has risen quickly through the New York standup ranks thanks to a style that mixes cagey political humor ("'gentrified' means when a bunch of white people move into a messed up neighborhood and open up cupcake stores everywhere") and broad, poignant observational bits (describing the difference between "love" and "like," he notes, "People kill their loved ones all the time. Nobody ever kills people they like"). Last year he debuted his first character in a series of shorts called "The Realest Candidate" for the Lorne Michaels-backed online comedy venture Above Average; he played a hip-hop artist/Republican strategist with a foolproof plan for job creation: "more Vodka companies!"