23. Hannibal Buress
Buress is our era's top inheritor of the late, lamented Mitch Hedberg's stoner comedy mantle, with a vaguely blitzed delivery and an ability to come up with brilliantly weird riffs on anything from the best use of pickle juice to the deficiencies of rap videos ("some of 'em say 'To Be Continued,' but they never have the second video. There's so much suspense! Are they gonna pour more champagne on these bitches or is somebody gonna bring a towel?"). The Chicago native got into comedy almost by accident ("I saw some other people, and I was like, 'These people are really bad. I can be really bad.' So I went on to be bad for a few years," he recalled recently), eventually landing writing gigs on Saturday Night Live and 30 Rock. The weekly stand-up nights he hosts in Williamsburg, Brooklyn's Knitting Factory have become an always-packed hipster must-see.