42. David Sedaris
The true breakout star from This American Life (sorry, Ira) remains America's favorite gay, Southern ex-Santa elf, the go-to humorist for folks who spend too much for a cup of coffee. His new book Let's Explore Diabetes with Owls is due in the spring while a feature film adaptation of his story, C.O.G. just debuted at Sundance. And word to his equally-bonkers sister Amy, who is responsible, whether true or not, for one of the the great spit-take moments in his mega-cringe-worthy canon: Exiting a subway, turning and yelling at her brother "Hey David...Good luck beating that rape charge!"